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Anxiety is not just an emotion, it may be an early manifestation of Alzheimer's disease (AD)! In a recent study, researchers found that Alzheimer's disease "related proteins" amyloid beta levels rise and anxiety There is a correlation between the worsening of symptoms.
High levels of amyloid associated with anxiety
Previous studies have shown that depression and other neuropsychiatric symptoms may be predictors of AD progression in its "preclinical" phase. During this time, fibrillar amyloid and tau protein accumulate in the patient's brain, which may occur more than a decade ago in patients with mild cognitive impairment.
This time, researchers at Brigham and Women's Hospital investigated the correlation between cerebral amyloid and longitudinal measurements of depressive symptoms in elderly cognitively, suggesting that high levels of amyloid may be associated with These people are associated with increased anxiety symptoms.
These results also support the theory that neuropsychiatric symptoms may be an early indicator of AD, and the findings were published in the Journal of The American Journal of Psychiatry on January 12.
Anxiety or an early indicator
Nancy Donovan, MD, MD, MD, MD, MD, MD, author of the elderly psychiatrist and women's hospital, said, "We don't just look at depression, but look at specific symptoms, such as anxiety. When compared to other depressive symptoms (such as sadness or loss of interest) The anxiety symptoms of people with higher levels of amyloid in the brain increase over time."
This suggests that symptoms of anxiety may be the manifestation of Alzheimer's disease before the onset of cognitive impairment. If further research confirms that anxiety is an early indicator, it is important not only for people who identify the disease early, but also for early treatment and potential processes for slowing or preventing disease.
Donovan said, “Because anxiety is common in the elderly, an increase in anxiety symptoms may prove to be the most useful risk indicator because older people have other genetic, biological or clinical indicators of risk.â€
Related research details
The researchers obtained data from the Harvard Aging Brain Study. The study was an observational study of elderly adult volunteers to determine the neurobiological and clinical changes in early Alzheimer's disease.
Participants included 270 community residents (men and women with normal cognition) between the ages of 62 and 90 without mental disorders. Participants also underwent baseline imaging scans commonly used in Alzheimer's disease studies and an annual assessment of 30 Geriatric Depression Scales (GDS), an assessment of depression in the elderly. The team calculated the total GDS scores for the three groups of depressive symptoms: no happiness, irritability, and anxiety.
The researchers found that elderly people with normal cognitive function, over time, increased amyloid beta protein load in the brain associated with increased anxiety. The results suggest that deteriorating anxiety and depressive symptoms may be an early predictor of elevated amyloid beta levels, which in turn supports the hypothesis that neuropsychiatric symptoms represent early manifestations of preclinical Alzheimer's disease.
Donovan said further longitudinal follow-up is needed to determine whether these escalating depressive symptoms will progress over time, leading to clinical depression and dementia in Alzheimer's disease.
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