Multiple sclerosis is an autoimmune disease that affects the patient's nervous system, resulting in the loss of the patient's physical and cognitive functions. Now, researchers have identified a factor that may affect progressive multiple sclerosis. The new results are published in the journal Nature-Immunology published online in August.
Multiple sclerosis has different types of disease progression patterns. Clinically, according to the progression of the disease, it can be divided into four categories: relapse-relief, secondary-progressive, first-progressive, and progressive-relapse. The progression of the disease can be simply divided into two stages. The recurrence-relief stage is mainly an inflammatory response caused by immunity, while the progressive stage includes nerve degeneration.
However, after the relapse-remission phase, the disease will develop irreversibly and progressively. There is currently no effective treatment for this progressive multiple sclerosis.
A research team led by Howard Weiner and Francisco Quintana identified a fat called 15-HC, which is increased in progressive patients but not in patients with relapse-remission. Scientists have discovered that 15-HC activates a receptor called PARP-1, which blocks PARP-1 activity and reduces the course of disease in mice with progressive multiple sclerosis.
Further research will confirm a new question: whether controlling PARP-1 activity is a potential method of treating progressive multiple sclerosis.
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