a. Uniformity. In a monoclonal antibody, the chemical structure and amino acid sequence of each antibody are the same, and there is only one Ig subclass. That is, monoclonal antibody is a homogeneous antibody with high purity. The polyclonal antibodies obtained from different animals and different periods have different chemical compositions. Polyclonal antibody is a mixture of various types and subclasses of Ig. b. Stability. The stability of the monoclonal antibody is poor, sensitive to pH changes, unstable to heat, and volatile during purification, while the stability of the polyclonal antibody is better. c. Specificity. Monoclonal antibody is a certain determinant of the antigen, so when it is used for serological reactions, it has strong specificity and high sensitivity, and generally no cross reaction occurs. The polyclonal antibody can bind to multiple antigenic determinants on the antigen, so the specificity is poor and cross-reaction is more likely to occur. d. Repeatability. The reproducibility of monoclonal antibodies is good, and polyclonal antibodies are different from batch to batch. e. Precipitation reaction. Multi-antibodies easily form network-like precipitates due to multivalent binding to antigens, while monoclonal antibodies only bind to antigens to produce dimers, and cannot directly form antigen-antibody precipitates. Source: Biotechnology Forum
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