The reporter learned from the University of Science and Technology of China that the research team of Professor Wen Longping of the School of Life Sciences of the school discovered a short peptide that can regulate the cell autophagy caused by rare earth nanomaterials, thereby greatly reducing the toxic and side effects of nanomaterials and improving the tumor cells Killing effect. Related papers have recently been published online in the internationally renowned academic journal "Nature? Materials".
Cellular autophagy is a key cellular biological process in which cells use lysosomes to degrade damaged organelles, macromolecular substances and long-lived proteins to maintain the homeostasis of cells, and is closely related to the occurrence, development and treatment of various major diseases. Recent studies have shown that inhalation and many nanoparticles entering the body for diagnosis and treatment can trigger cell autophagy and promote cell death. This kind of nanoparticle-induced cellular autophagy is a double-edged sword. On the one hand, it will cause toxicity in normal cells and needs to be circumvented. On the other hand, it can be used in specific cells to help disease treatment, such as enhancing cancer radiotherapy and chemotherapy And the effect of immunotherapy, treatment of neurodegenerative diseases (such as Parkinson's disease, etc.). The effective regulation of the autophagy effect caused by nanoparticles will greatly promote the in vivo application of nanomaterials and nanodevices.
Wen Longping's team used "phage display" technology to discover a short peptide RE-1. It can combine with rare earth metal oxides and rare earth up-conversion luminescent nanomaterials, and form a stable peptide coating on its surface. Experiments in mice have shown that the short peptide can reduce the level of autophagy by inhibiting the interaction between nanoparticles and cells, thereby shielding cytotoxicity and tissue damage caused by autophagy, and improving the biological safety of nanomaterials. On the other hand, the short peptide and the compound peptide composed of a short peptide RGD capable of recognizing tumors interact with integrin outside the tumor cells to improve the autophagy and killing effect of the rare earth nanomaterials in the tumor cells. Therefore, the discovery is expected to simultaneously achieve the goal of shielding autophagy in normal cells and increasing autophagy in tumor cells to enhance chemotherapy.
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