Abnormal calcium concentration can cause congenital heart disease. Japanese researchers published a paper in the latest issue of the "Public Science Library · General" magazine that when the fetus is formed, if it has problems in regulating the intracellular calcium concentration, it will cause calcium If the concentration is abnormal, the fetus cannot form the ventricular wall, which leads to congenital heart disease. About 1% of newborns in Japan have some abnormalities in their hearts every year, and 10% of miscarriages are caused by fetal congenital heart disease. The joint research group of Keio University and the Institute of Physico-Chemistry has genetically manipulated fetuses of mice that do not contain type I and type II inositol triphosphate receptors. Inositol triphosphate receptors are proteins that regulate calcium concentration in cells. As a result, it was found that the cells that made the ventricular wall in the fetus of the mouse disappeared. The researchers say that this is because calcium ions are needed to generate ventricular wall and valve cells, and the abnormal calcium concentration in the cells will cause the calcium ions to not function properly. Keiyama Kishi of Keio University said that the new results provide new ideas for the prevention of congenital heart disease.
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